Pregnyl® 5000 IU (Organon)

Brand Name: Pregnyl®
Generic Name: Human Chorionic Gonadotropin (hCG)
Manufacturer: Organon
Dosage Form: Lyophilized Powder with Solvent for Injection
Strength: 5000 IU
Administration Route: Intramuscular (IM)

Product Overview

Pregnyl® 5000 IU is a gonadotropin hormone preparation containing Human Chorionic Gonadotropin (hCG), a hormone naturally produced during pregnancy. It is widely used in fertility treatments and hormonal therapies for both men and women. The product comes as a sterile, freeze-dried powder that must be reconstituted with the provided solvent before injection.

Key Benefits

• Triggers ovulation in women
• Supports treatment of female infertility
• Stimulates testosterone production in men
• Helps improve sperm production (spermatogenesis)
• Used in assisted reproductive techniques (ART)

Mechanism of Action

Pregnyl® works by mimicking luteinizing hormone (LH). It stimulates the ovaries to release an egg (ovulation) in women and activates Leydig cells in males to produce testosterone, supporting reproductive function.

Indications / Uses

In Women:

• Ovulation induction in anovulatory infertility
• Follicular maturation in assisted reproduction

In Men:

• Hypogonadotropic hypogonadism
• Delayed puberty
• Cryptorchidism (undescended testes)

Dosage & Administration

• Typically administered after gonadotropin therapy
• Common dose: 5000–10,000 IU as directed by a physician
• Inject only after proper reconstitution

Reconstitution Instructions

• Dissolve the dry powder using the supplied solvent
• Mix gently—do not shake
• Use immediately or store refrigerated (2–8°C) if needed
• Discard unused portion after recommended time period

Side Effects

• Injection site pain
• Headache
• Fluid retention
• Mood changes
• Risk of ovarian hyperstimulation (in females)

Precautions

• Avoid in hormone-sensitive tumors
• Use cautiously in heart, kidney, or endocrine disorders
• Not recommended without proper fertility evaluation
• Regular monitoring is required during treatment

Storage Instructions

• Store below 25°C before reconstitution
• After mixing, refrigerate at 2–8°C
• Protect from light
• Do not freeze

Pack Size

• 1 vial (5000 IU) + 1 ampoule solvent

Disclaimer

Pregnyl® 5000 IU is a prescription medication and should only be used under the guidance of a qualified healthcare professional. Misuse can lead to serious health complications.