Testosterone undecanoate

Testosterone Undecanoate: Long-Acting Benefits, Uses and Potential Risks

Testosterone Undecanoate is a long-acting ester of testosterone used in testosterone replacement therapy for men with clinically confirmed low testosterone levels. It is available in both oral and intramuscular formulations, depending on the specific product and market.

Because it is a long-acting testosterone ester, its pharmacokinetic profile differs from shorter-acting testosterone preparations.

Testosterone Undecanoate: Key Information

• Oral Trade Names: Andriol, Jatenzo
• Intramuscular Trade Names: Aveed, Nebido
• Other Names: TU, Testosterone Undecylate, Testosterone 17β-Undecanoate, ORG-538, CLR-610
• Classification: Androgen, anabolic steroid, androgen ester
• Routes of Administration: Oral and intramuscular injection
• Oral Bioavailability: Approximately 3–7% according to the supplied material
• Intramuscular Bioavailability: High
• Reported Half-Life: The supplied material lists approximately 20.9 days for one IM formulation and 33.9 days for another

History of Testosterone Undecanoate

The supplied material states that Testosterone Undecanoate was introduced during the 1970s and later developed for intramuscular administration. Injectable formulations became available in European countries around 2000 and in the United States around 2014.

Medical Uses of Testosterone Undecanoate

Testosterone Undecanoate is primarily associated with testosterone replacement therapy for men with low testosterone levels when treatment is medically indicated.

Potential therapeutic goals may include restoring testosterone levels and addressing symptoms associated with testosterone deficiency, such as:

• Low energy
• Reduced libido
• Changes in mood
• Reduced muscle mass
• Reduced strength
• Other symptoms associated with testosterone deficiency

Treatment should be based on appropriate clinical evaluation and laboratory testing.