Evogene Alley Pharmaceuticals

Human Growth Hormone (HGH), also known as somatropin, is a hormone secreted by the anterior pituitary gland, located deep within the brain. It is a single-chain polypeptide consisting of 191 amino acids and is one of the five major hormones produced by the pituitary gland.

The other four are:

Adrenocorticotropic hormone (ACTH)

Thyroid-stimulating hormone (TSH)

Follicle-stimulating hormone (FSH)

Luteinizing hormone (LH)

HGH plays a crucial role in growth and metabolic regulation, especially during adolescence. It influences protein synthesis, muscle growth, red blood cell production, and organ development.

Physiological Function

Secretion: HGH is primarily secreted during sleep.

Metabolism: It is transformed by the liver into insulin-like growth factor 1 (IGF-1), which mediates most of HGH's effects.

Effects: Promotes rapid growth, metabolic rate, and protein synthesis.

Historical Context & Production

First treatment: In 1958, HGH was first used, extracted from cadaver pituitary glands.

Risks: In 1985, the FDA banned cadaver-derived HGH due to its association with Creutzfeldt-Jakob’s disease (CJD).

Synthetic HGH: The first synthetic HGH was approved in the same year, initially called somatrem—a slightly different amino acid sequence but with similar biological properties.

Advancement: In 1987, somatropin was produced, matching the exact amino acid sequence of endogenous HGH, making it the standard form used today.

Formulations & Administration

Common Forms: Most HGH products are somatropin.

Routes: Suitable for subcutaneous or intramuscular injection.

Potency: 1 mg of somatropin ≈ 3 IU.

Dosing Range: Typically 0.03 IU/kg to 0.06 IU/kg per 24 hours.

Injection Schedule: Usually two injections per day, dividing the total daily dose.

Metabolism: After injection, HGH is metabolized by the liver into IGF-1.

Feedback Loop: Elevated IGF-1 levels inhibit natural HGH production via a negative feedback loop.

Usage & Effects
Growth Retarded Children: HGH may suppress thyroid function in less than 50% of cases, often requiring thyroid hormone supplementation.
Adults: Rarely causes thyroid suppression; supplementation only if blood tests indicate need.
Treatment Duration: Usually at least 3 months before results are observed.

Effects:
Fat loss (most prominent)
Muscle growth
Increased strength
Enhanced athletic performance

Precautions & Interactions
Estrogen/Androgen Interaction: High circulating testosterone levels and low estrogen levels can influence feedback regulation.
Estrogen Suppression: Use compounds that don't aromatize much, or add Arimidex or letrozole as backup.

Storage: Keep at 2-8°C (refrigerated).

Post-mixing: Do not shake the solution; molecules are fragile.

Usage Window: Use the reconstituted solution within 48 hours, ideally within 24 hours.

Degradation: Some sources indicate the solution degrades quickly after mixing.

Summary

HGH (somatropin) is a potent hormone with significant anabolic and fat-burning properties, used medically and for performance enhancement under proper medical supervision. Its effectiveness depends on correct dosing, administration, and management of hormonal interactions.